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Bruk av antidepressive midler og antipsykotika er ikke uvanlig ved akutte korsryggssmerter, til tross for det ikke finnes dokumentert effekt av disse på smerter eller sykdomsforløp.Trisykliske antidepressiver (der i blant amitriptylin) har hos nyfødte barn gitt abstinenssymptomer i type av skjelvinger og kramper og i enkelte tilfeller gitt sløv